Daim ntawv thov ntawm Ultrasonic Homogenization hauv Kev Lag Luam Pharmaceutical

Hauv kev lag luam kws tshuaj hloov pauv mus rau ntsuab thiab precision manufacturing, ultrasonic homogenization tshuab, nrog nws cov cim lub cev los, tau kov yeej ntau bottlenecks nyob rau hauv cov txheej txheem ib txwm, los ua ib tug tseem ceeb thev naus laus zis txhais tau tias nyob rau hauv kev tshawb fawb tshuaj thiab ntau lawm. Cov thev naus laus zis no siv high-ntau zaus ultrasound los ua kom muaj cavitation, tshuab shearing, thiab turbulent cuam tshuam, tsim kom muaj qhov chaw siab - kub, siab - siab microenvironment hauv cov kua nruab nrab. Qhov no ua tiav cov khoom ua kom zoo dua qub, dispersion, emulsification, thiab kev cuam tshuam ntawm tes, muaj cov txiaj ntsig zoo ntawm kev ua haujlwm siab, ua siab mos siab muag, thiab tswj tau.

Core Application Scenarios

I. Extraction thiab cais cov khoom xyaw nquag

Nyob rau hauv zus tau tej cov tshuaj ntsuab thiab biopharmaceutical tshuaj, ultrasonic homogenization tshuab ho optimizes lub extraction efficiency ntawm active cov khoom xyaw. Hais txog cov teeb meem ntawm lub sij hawm-siv thiab siab tivthaiv poob cuam tshuam nrog cov tsoos boiling thiab dej los nag txoj kev, ultrasound tuaj yeem cuam tshuam cov phab ntsa ntawm tes los yog microbial cell membranes los ntawm cavitation, ua kom cov kuab tshuaj nkag mus sai thiab tso tawm cov khoom. Lub sij hawm rho tawm raug txo kom tsawg dua ib -feem peb ntawm cov txheej txheem ib txwm muaj, thiab cov txiaj ntsig ntawm cov khoom xyaw nquag tau nce ntau dua 30%. Txawm hais tias extracting polysaccharides los ntawm Ganoderma lucidum spores los yog cais cov recombinant proteins los ntawm E. coli, lub thev naus laus zis no khaws cov khoom siv hauv cov xwm txheej zoo, tsis txhob muaj kev sib kis los ntawm cov tshuaj reagents ntxiv thiab tso lub hauv paus rau cov txheej txheem purification tom ntej.

II. Kev npaj cov tshuaj tshiab tshiab

Hauv kev tsim cov qauv tshiab xws li nano-formulations, liposomes, thiab tshuaj tsuag qhov ntswg, ultrasonic homogenization yog cov cuab yeej tseem ceeb rau kev ua tiav cov qauv tsim. Los ntawm kev rhuav tshem cov particle agglomerates los ntawm lub zog shear quab yuam, cov khoom loj me me thiab kev ruaj ntseg siab nano- cov tshuab dispersion tuaj yeem npaj tau, txhim kho tus nqi tawg thiab bioavailability ntawm cov tshuaj tsis zoo soluble. Piv txwv li, hauv kev tsim cov tshuaj tsuag qhov ntswg rau COVID-19 kev tiv thaiv, tshuab ultrasonic emulsification tuaj yeem tsim micro- thiab nano-scale dispersed theem, txhim kho cov tshuaj adsorption muaj peev xwm thiab lub sij hawm tuav ntawm cov mucous daim nyias nyias, thiab txhim kho cov nyhuv antibacterial; nyob rau hauv cov tshuaj anticancer formulations, nws tuaj yeem tswj cov tshuaj me me kom qis dua qib micrometer, pab cov tshuaj nkag mus rau cov ntaub so ntswg thiab txhim kho kev kho mob.

III. Yam tseem ceeb ntawm kev tsim tshuaj tiv thaiv

Ultrasonic homogenization plays lub luag haujlwm tseem ceeb hauv kev npaj tshuaj tiv thaiv tag nrho. Nyob rau hauv lub antigen extraction theem, nws maj mam zom cov kab mob los yog kab mob hlwb, zoo tso intracellular tshuaj xws li cov proteins thiab antigens thaum maximizing antigen kev ua. Nyob rau hauv lub formulation theem, nws ua tiav zoo dispersion ntawm txhuas-raws li adjuvants thiab antigens, tiv thaiv kev sib sau ua ke uas yuav cuam tshuam rau kev txhaj tshuaj tiv thaiv kab mob. Ib txhij, nws tuaj yeem siv rau cov kab mob tsis ua haujlwm, emulsification, thiab degassing hauv kev tsim cov tshuaj tiv thaiv, ua kom cov tshuaj tiv thaiv tsis sib xws thiab kev nyab xeeb thiab muab kev txhawb nqa ruaj khov rau cov khoom loj -.

IV. Aseptic Sieving thiab Impurity Tshem Tawm

Nyob rau hauv cov tshuaj micronized hmoov sieving txheej txheem, ultrasonic homogenization tshuab zoo daws qhov teeb meem ntawm mesh clogging. Los ntawm kev siv lub siab - zaus ultrasonic transducer resonate nrog lub vijtsam mesh los ua ib qho chaw sawv yoj, cov hmoov micronized tau dhia dhia. Rau cov khoom siv yooj yim xws li vitamin C thiab caffeine, lub sieving throughput stability tuaj yeem tswj tau siab tshaj 98%, nrog rau 75% txo cov seem. Piv nrog rau cov tsoos airflow sieving, nws txo lub zog noj los ntawm 65%, yog haum rau nplua sieving scenarios ntawm 325 mesh thiab saum toj no, thiab muaj peev xwm nruj me ntsis xyuas kom meej lub purity thiab batch sib xws ntawm formulation, ua tau raws li cov kev cai tswj kom zoo ntawm kev lag luam kws tshuaj.